NKL 22 (MDK-4154) for cell activation
Catalog number
B1133-10
Name
NKL 22 (MDK-4154) for cell activation
Size
10 mg
Price
208.00 EUR
Supplier
Details
Description
NKL 22 (also known as MDK-4154) is a cell-permeable compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. It reverses the silencing of FXN transcription in FRDA (Friedreich’s ataxia) cells due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K12, and H4K5 without much acetylation on H3K9, H4K8 and H4K16.
Peptide sequence
N/A
CAS number
537034-15-4
Molecular weight
325.4
Category
Biochemicals
Other name
N1-(2-aminophenyl)-N7-phenylheptanediamide
Molecular formula
C₁₉H₂₃N₃O₂
Physical appearance
Beige to pale white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (100 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
