RBC8 for cell activation

RBC8 is cell-permeable small molecule that inhibits the binding of Ras-like GTPases A and B ( RalA and RalB GTPase ) to RaLBP1 and shown to suppress growth of xenograft tumors in mice. It reduces the activation of RaiA in living cells Ral is needed for the growth of murine embryonic fibroblasts (MEFs). Ral pull down assay showes that RBC8 inhibits the activation of both RalA and RalB in the H2122 and H358 cell lines.

N/A

361185-42-4

424.45

Biochemicals

6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile

C₂₅H₂₀N₄O₃

White Solid

N/A

No

Yes

≥98% by HPLC

DMSO (> 40 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.