GNF-7 for cell activation

GNF-7 is a multi-targeted kinase inhibitor that inhibits activated CDC42 kinase 1 (ACK1) and germinal center kinase (GCK) inducing cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. It also displays significant in vivo efficacy against T315l-Bcr-Abl without notable toxicity in a bioluminescent xenograft mouse model using transformed T315l-Bcr-Abl-Ba/F3 cell line that has a stable luciferase expression.

N/A

839706-07-9

547.53

Biochemicals

N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide

C₂₈H₂₄F₃N₇O₂

White Solid

N/A

No

Yes

≥98% by HPLC

DMSO (>30 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.