AZ-3146 for cell activation
Catalog number
B1145-5
Name
AZ-3146 for cell activation
Size
5 mg
Price
186.00 EUR
Supplier
Details
Description
AZ 3146 is a potent and selective Mps1 (monopolar spindle 1) kinase inhibitor (IC₅₀ = 35 nM). Shows selectivity over 46 other kinases including aurora kinase B and Cdk1. AZ 3146 overrides spindle assembly checkpoint and also interferes with chromosome alignment. It has shown to inhibit the recruitment of Mad1, 2 and centromere protein E (CENP-E) to kinetochores.
Peptide sequence
N/A
CAS number
1124329-14-1
Molecular weight
452.55
Category
Biochemicals
Other name
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Molecular formula
C₂₄H₃₂N₆O₃
Physical appearance
White Solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO(>10 mg/ml))
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
