MPEP hydrochloride for cell activation
Catalog number
B1151-50
Name
MPEP hydrochloride for cell activation
Size
50 mg
Price
588.00 EUR
Supplier
Details
Description
MPEP hydrochloride is a highly selective and potent non-competitive antagonist at the mGlu5 (metabotropic glutamate receptor subtype 5) receptor subtype (IC₅₀ = 36 nM). It is a positive allosteric modulator at mGlu4. MPEP hydrochloride reduces DHPG (S-3, 5-dihydroxyphenylglycine)-induced excitations but not the excitations induced by AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). In vivo studies show it reverses mechanical hyperalgesia in the inflamed rat hind paw.
Peptide sequence
N/A
CAS number
219911-35-0
Molecular weight
229.71
Category
Biochemicals
Other name
2-Methyl-6-(phenylethynyl)pyridine hydrochloride
Molecular formula
C₁₄H₁₁N.HCl
Physical appearance
White Solid
Supplied with
N/A
Is this a salt?
Yes
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
