Triapine for cell activation

3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. In addition, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.

N/A

143621-35-6

195.24

Biochemicals

3-Aminopyridine-2-Carboxyaldehyde Thiosemicarbazone; 3-AP; NSC 663249

C₇H₉N₅S

White to off-white solid

N/A

N/A

Yes

≥98% by HPLC

DMSO (~20 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.