R162 for cell activation

R162 is a cell-permeable, nontoxic selective inhibitor of Glutamate Dehydrogenase 1 (GDH1), (Ki = 28.6 µM) which is an upregulated enzyme in human cancers. It shows selectivity over other NADPH-dependent enzymes such as 6-phosphogluconate dehydrogenase (6PGD) and Fumarate hydratase (FH). It showes reduced levels of intracellular fumarate levels and Glutathione peroxidase (GPx) activity with increase in mitochondrial ROS levels. Decreases the tumor growth and inhibits the cancer cell proliferation of H1299 and primary leukemia cells.

N/A

64302-87-0

264.28

Biochemicals

1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione

C₁₇H₁₂O₃

Orange solid

N/A

N/A

Yes

≥98% by TLC

DMSO (>10 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.