R162 for cell activation

Catalog number
B1180-5
Name
R162 for cell activation
Size
5 mg
Price
142.00 EUR
Supplier

Details

Description
R162 is a cell-permeable, nontoxic selective inhibitor of Glutamate Dehydrogenase 1 (GDH1), (Ki = 28.6 µM) which is an upregulated enzyme in human cancers. It shows selectivity over other NADPH-dependent enzymes such as 6-phosphogluconate dehydrogenase (6PGD) and Fumarate hydratase (FH). It showes reduced levels of intracellular fumarate levels and Glutathione peroxidase (GPx) activity with increase in mitochondrial ROS levels. Decreases the tumor growth and inhibits the cancer cell proliferation of H1299 and primary leukemia cells.
Peptide sequence
N/A
CAS number
64302-87-0
Molecular weight
264.28
Category
Biochemicals
Other name
1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
Molecular formula
C₁₇H₁₂O₃
Physical appearance
Orange solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
Yes
Purification
≥98% by TLC
Reconstitute instructions
DMSO (>10 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.