SR9009 for cell activation

SR9009 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB α (IC50=670 nM) and REV-ERBβ (IC50 = 800 nM). SR9009 decreases the circadian locomotor activity during dark phase through activation of REV-ERB, altering the expression pattern of core clock genes in the hypothalamai of mice. In in vivo experiments SR9009 has shown to decrease body fat and improved dyslipidemia and hyperglycemia.

N/A

1379686-30-2

437.94

Biochemicals

 Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate

C₂₀H₂₄ClN₃O₄S

Off White solid

N/A

No

Yes

≥98% by HPLC

DMSO(>40 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.