EPZ011989 for cell activation

Catalog number

B1221-25

Size

25 mg

Price

757.00 EUR

Supplier

Biovision

Order

Details

Description

EPZ011989 is a potent EZH2 inhibitor with Ki values that are less than 3 nM for wild type and Tyr646 mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an array of other lysine methyltransferases. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.

Peptide sequence

N/A

CAS number

1598383-40-4

Molecular weight

605.82

Category

Biochemicals

Other name

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Molecular formula

C₃₅H₅₁N₅O₄

Physical appearance

Off-white solid

Supplied with

N/A

Is this a salt?

Is it cell-permeable?

Yes

Purification

≥98% by HPLC

Reconstitute instructions