GSK2256098 for cell activation

GSK2256098 (GTPL7939) is a focal adhesion kinase-1 (FAK-1) inhibitor with potential antineoplastic and antiangiogenic activity. FAK is normally activated by integrin binding to extra cellular matrix and might be upregulated and activated in various tumor types. This inhibition of FAK-1 kinase prevents downstream signal transduction pathways mediated by integrin activation including ERK, JNK/MAPK and PI3/Akt thus inhibiting tumor cell migration, proliferation and survival.

N/A

1224887-10-8 

414.89

Biochemicals

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

C₂₀H₂₃ClN₆O₂ 

White to off-white solid

N/A

No

Yes

≥98% by HPLC

DMSO

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.