DiscoveryPak™ Receptor Tyrosine Kinase (RTK) Inhibitor Set for cell activation

Catalog number
K859-8
Name
DiscoveryPak™ Receptor Tyrosine Kinase (RTK) Inhibitor Set for cell activation
Size
8 inhibitors
Price
779.00 EUR
Supplier

Details

Description
A convenient set consisting of eight Receptor Tyrosine Kinase (RTK) inhibitors. The eight inhibitors are: 5 mg of Axitinib (Cat. No. 1581-5), 5 mg of Canertinib (Cat. No. 1617-5), 5 mg of Gefitinib (Cat. No. 1589-5), 5 mg of GW2580 (Cat. No. 1740-5), 25 mg of Lapatinib Ditosylate (Cat. No. 1624-25), 1 mg of PD-173074 (Cat. No. 1675-1), 1 mg of SB-431542 (Cat. No. 1674-1), and 100 mg of Sunitinib Malate (Cat. No. 1611-100).
Peptide sequence
N/A
CAS number
See under the individual product
Molecular weight
See under the individual product
Category
Biochemicals
Other name
Receptor Tyrosine Kinase (RTK) Inhibitor Set, DiscoveryPak™
Molecular formula
See under the individual product
Physical appearance
Lyophilized solids
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air, light and moisture
Tissue
cell, set
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.