DiscoveryPak™ Stem Cell Fate Regulator Set IX (VC6TFZ) for cell activation

A convenient set of six small molecule modulators (V6CTFZ) useful for generation of iPSC’s (induced pluripotent stem cells) from mouse somatic cells. The six modulators are: 200 mg of Valproic acid sodium salt (VPA) (Cat. No. 1647-200), 5 mg of CHIR99021 (Cat. No. 1677-5), 5 mg of RepSox (E-616452) (Cat. No. 1894-5), 25 mg of Tranylcypromine Hemisulfate (Parnate) (Cat. No.1816-25), 5 mgof Forskolin (Cat. No. 1531-5) and 1 mg of 3-Deazaneplanocin A (Cat. No. 2060-1000).

N/A

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Biochemicals

VC6TFZ

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Lyophilized solids

N/A

No

Y

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See under the individual product

-20°C

Gel Pack

36 months

Protect from air and light

cell, set, stem

For cells, cell lines and tissues in culture till half confluency.

Stem cell factors and stem cell growth factors will produce stem cells or be part of a transdifferentiation process to produce other cells. A cell can transdifferentiate by going back to the naive stem cell stadium or directly into the other cell, helped by the stem cell and transdifferentiationf actors. Stem cell growth factors or stem cell factors are mostly used to produce iPSCs or induced pluripotent stem cells by Jamaka or Thomson factors by using for example 5 Lenti-III-CMV viruses, expressing the Yamanaka iPSC factor set (Oct4, Sox2, Nanog and Lin28) + GFP positive control. Trans differentiation will omit the stem cell stadium but stem cell factors sill play an important role in trans differentiation strategies.