Urokinase Inhibitor Screening Kit (Fluorometric)

Urokinase (Urokinase-type plasminogen activator, uPA, EC 3.4.21.73) is a serine protease, which catalyzes the conversion of the plasminogen to active plasmin, which in turn participates in thrombolysis. Urokinase inhibitors have potential applications in cancer therapy. Biovision’s Urokinase Inhibitor Screening Kit utilizes the ability of Urokinase to cleave a synthetic AMC-based peptide substrate to release AMC, which can be detected by measuring its fluorescence at Ex/Em = 350/450 nm. In the presence of the Urokinase specific inhibitors, the enzyme activity is inhibited or completely abolished. This assay kit is a simple, sensitive, and rapid tool to screen potential Urokinase inhibitors.

• Detection Method – Fluorescence (Ex/Em = 350/450 nm) • Application: : Screening potential inhibitors of Urokinase : Characterize/study urokinase inhibitors

• Rapid & simple • Reliable test for screening potential inhibitors of Urokinase • Includes Urokinase-specific Inhibitor [GGACK Dihydrochloride]

Urokinase

uPA Inhibitor Screening Kit (Fluorometric), urokinase-type plasminogen activator Inhibitor Screening Kit (Fluorometric)

• Urokinase Assay Buffer • Urokinase Substrate • Human Urokinase • Urokinase Inhibitor [GGACK Dihydrochloride] (10 mM)

-20°C

gel pack

12 months

see datasheet

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Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.