Cytochrome P450 1A2 (CYP1A2) Inhibitor Screening Kit (Fluorometric)

-20°C

High-throughput compatible, quick and easy screening for CYP1A2 inhibitors or ligands; Includes human CYP1A2 - NADPH Reductase.

gel pack

12 months

Eukaryotes

• Rapid, high-throughput screening of drugs and novel ligands. • Development of structure-activity relationship (SAR) models to predict CYP1A2 inhibition liability of novel compounds. • Prediction of adverse drug-drug interaction potential and bioavailability for compounds metabolized by CYP1A2.

Samples containing drugs, inhibitors or ligands (compounds that can interact and affect CYP1A2 activity)

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.