LRRK2 (Human) ELISA Kit

Leucine-rich repeat serine/threonine-protein kinase 2 positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. BioVision’s LRRK2 ELISA kit is a sandwich ELISA assay for the quantitative measurement of human LRRK2 in serum, plasma and cell culture supernatants. The density of color is proportional to the amount of LRRK2 captured from the samples.

• Detection method: Absorbance (450 nm) • Species reactivity: Human • Application: quantitative measurement of LRRK2 in human serum, plasma, tissue homogenates and other biological fluids.

Easy, convenient and time-saving method to measure the level of LRRK2 in human serum, plasma, tissue homogenates, culture supernatants and other biological fluids. Detection Range: 0.156-10 ng/ml Sensitivity: < 0.094 ng/ml

ELISA kit

none

• Microplate: 96 wells • Lyophilized Standard • Sample / Standard dilution buffer • Biotin- detection antibody (Concentrated) • Antibody dilution buffer • HRP-Streptavidin Conjugate (SABC) • SABC dilution buffer • TMB substrate • Stop Solution • Wash buffer (25X) • Plate sealers

4°C

gel pack

6 months

Human

Quantitative measurement of LRRK2 in human serum, plasma, tissue homogenates and other biological fluids.

Human serum, plasma, tissue homogenates and other biological fluids.

E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

ELISA Enzyme-linked immunosorbent assays Code 90320007 SNOMED