Human Tau-441 Recombinant protein
Catalog number
P1192-250
Name
Human Tau-441 Recombinant protein
Size
250 μg
Price
1023.00 EUR
Supplier
Details
Scientific context
Tau is a microtubule-associated protein involved in Alzheimer’s and Parkinson’s disease. It promotes microtubule assembly and stability, and might participate in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Specific targetted sequence
MGSSHHHHHHSSGLVPRGSH - MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
Molecular weight (in Da)
48 kDa
Protein target
MAPT
Other name
MAPTL, MTBT1, TAU, Neurofibrillary tangle protein, Paired helical filament-tau
Gene origin
Human
Gene number
4137 (MAPT)
Protein number
P10636
Source
E.coli
Application
SDS-PAGE (Purity > 90% )
Endotoxins
N/A
Specific activity
N/A
Bioactivity
N/A
Example results
N/A
Unit Definition
N/A
Handling and storage
Centrifuge the vial prior to opening. Store for 12 months at -20°C
Delivery
Shipped under gel pack
Package form
This product is supplied as lyophilized form in PBS
Reconstitute
Reconstitute to 4 mg/mL in sterile water.
Precautions
Manufactured in USA. For Research Use Only! Not to be used in humans
Released
Manifactured since May 2017. Available to order. Please contact us for larger or bulk quantity
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants
