Curcubitacin E

Catalog number

B1592-1

Name

Curcubitacin E

Size

1 mg

Price

153.00 EUR

Supplier

Biovision

Order

Details

Description

Curcubitacin E is a potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to Jasplakinolide (Cat. No. 1689), binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Acts as an immunomodulator with anti-inflammatory and anti-tumorigenic properties in a range of cancer cell lines, mediated by its action on the cellular cytoskeleton, on mitotic pathways as well as on cellular autophagy.

Chemical complete name

Cuc E; α-Elaterin; α-Elaterine; NSC106399; BRN2343323

CAS number

18444-66-1

Physical state

Off-white solid

Chemical formula

C₃₂H₄₄O8₈

Molecular weight (in Da)

556.7

Assay purity

≥98% by HPLC