Human CellExp PD-1 /PDCD1, C-Fc Tag, mouse recombinant

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PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l

Inhibits the T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.

PD-1/PDCD1

18566

PDCD1

Mouse

Q02242

Yes

HEK293 cells

N/A

N/A

Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse PD-1 /PDCD1 Fc Chimera at 2 µg/mL (100 µl/well) can bind biotinylated Mouse PD-L1 with a linear range of 32 - 500 ng/mL.

Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse PD-1 /PDCD1 Fc Chimera at 2 µg/mL (100 µl/well) can bind biotinylated Mouse PD-L1 with a linear range of 32 - 500 ng/mL.

This protein is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 43.2 kDa. The predicted N-terminus is Ser 21. DTT-reduced Protein migrates as 60-66 kDa in SDS-PAGE due to glycosylation.

-20°C

Gel Pack

1 year

N/A

Lyophilized

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM glycine, pH 7.5. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Centrifuge the vial prior to opening.

For Research Use Only! Not to be used in humans

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Mus musculus

Recombinants or rec. proteins

recombinants