GSK-LSD1 dihydrochloride

Catalog number
B1258-5
Name
GSK-LSD1 dihydrochloride
Size
2X5 mg
Price
340.00 EUR
Supplier

Details

Alternate Name/Synonyms
N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine dihydrochloride
Appearance
White to off-white solid
Formulation
N/A
CAS Number
1431368-48-7 (free base)
Peptide sequence
N/A
Molecular Formula
C14H22Cl2N2
Molecular Weight
289.24
Purity
≥98% by HPLC
Solubility/Reconstitution Instructions
H₂O (>20 mg/ml)
Handling
Protect from air and moisture
Tagline
A potent and selective lysine specific demethylase 1 (LSD1)inhibitor
Storage Temp.
-20°C
Shipping Conditions
gel pack
Shelf Life
36 months
MDL Number
N/A
PubChem CID
71522234
Category
Biochemicals
Gene
Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.