BTK Inhibitor, CNX-774 for cell activation

Catalog number
2600-5
Name
BTK Inhibitor, CNX-774 for cell activation
Size
5 mg
Price
186.00 EUR
Supplier

Details

Description
CNX-774 is a potent, irreversible BTK inhibitor (IC₅₀ < 1 nM). CNX-774 is highly selective for BTK, and forms a ligand-directed covalent bond with the Cys-481 residue within the ATP binding site of the enzyme.
Peptide sequence
N/A
CAS number
1202759-32-7
Molecular weight
499.5
Category
Biochemicals
Other name
4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
Molecular formula
C₂₆H₂₂FN₇O₃
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>98% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20 ̊C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.