Vinorelbine Tartrate for cell activation

Catalog number
1957-5
Name
Vinorelbine Tartrate for cell activation
Size
5 mg
Price
126.00 EUR
Supplier

Details

Description
A semi-synthetic vinca alkaloid that displays potent anti-mitotic and anti-tumor properties. Its main mechanism of action is thought to be inhibition of microtubule dynamics, which results in mitotic arrest and eventual cell death. Acts as a microtubule destabilizing agent. At high concentrations, it stimulates microtubule depolymerization and mitotic spindle destruction. At lower clinically relevant concentrations, vinorelbine blocks mitotic progression. Its main targets are tubulin and microtubules. Unlike the taxanes, which bind poorly to soluble tubulin, vinorelbine can bind both soluble and microtubule-associated tubulin.
Peptide sequence
N/A
CAS number
125317-39-7
Molecular weight
1079.11
Category
Biochemicals
Other name
3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate
Molecular formula
C₄₅H₅₄N₄O₈.C₈H₁₂O₁₂
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
Water (~ 10 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
48 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.