Harmine for cell activation

Catalog number
2561-50
Name
Harmine for cell activation
Size
50 mg
Price
132.00 EUR
Supplier

Details

Description
Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC₅₀’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM). Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation. Selective competitive and reversible inhibitor of MAO-A (IC₅₀ = 8 µM). Also regulates PPARγ expression and displays antidiabetic activity.
Peptide sequence
N/A
CAS number
442-51-3
Molecular weight
212.25
Category
Biochemicals
Other name
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
Molecular formula
C₁₃H₁₂N₂O
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by titration
Reconstitute instructions
DMSO (>20 mg/ml)
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.