Aftin-4 for cell activation

Catalog number
2574-1
Name
Aftin-4 for cell activation
Size
1 mg
Price
132.00 EUR
Supplier

Details

Description
A Roscovitine-related purine derivative that selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
Peptide sequence
N/A
CAS number
866893-90-5
Molecular weight
368.48
Category
Biochemicals
Other name
N6-Methyl-(R)-roscovitine; Amyloid-β Forty-Two Inducer 4
Molecular formula
C₂₀H₂₈N₆O
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by NMR
Reconstitute instructions
DMSO or EtOH
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.