GSK2830371 for cell activation

Catalog number
2578-1
Name
GSK2830371 for cell activation
Size
1 mg
Price
142.00 EUR
Supplier

Details

Description
GSK2830371 is an allosteric Wip1 (Wild type p53-induced phosphatase) inhibitor (IC₅₀ of 6 nM). It binds to a flap subdomain that regulates Wip1's enzymatic activity and substrate recognition. Due to lack of this domain in other phosphatases, its binding to GSK2830371 results in a selective and potent inhibition of Wip1. Treatment of tumor cells with the inhibitor GSK2830371 increases phosphorylation of Wip1 substrates and causes growth inhibition in both hematopoietic tumor cell lines and Wip1-amplified breast tumor cells harboring wild-type TP53.
Peptide sequence
N/A
CAS number
1404456-53-6
Molecular weight
461.02
Category
Biochemicals
Other name
GSK-2830371
Molecular formula
C₂₃H₂₉CN₄O₂S
Physical appearance
Off-white to pale yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.