Lactacystin (Synthetic) for cell activation

Catalog number
1709-200
Name
Lactacystin (Synthetic) for cell activation
Size
200 µg
Price
300.00 EUR
Supplier

Details

Description
Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC₅₀ = 10 µM).
Peptide sequence
N/A
CAS number
133343-34-7
Molecular weight
376.42
Category
Biochemicals
Other name
2-(acetylamino)-3-[({3-hydroxy-2-[1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)sulfanyl]propanoic acid
Molecular formula
C₁₅H₂₄N₂O₇S
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95% by HPLC
Reconstitute instructions
DMSO (25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.