Phlorizin for cell activation

Catalog number
2416-100
Name
Phlorizin for cell activation
Size
100 mg
Price
110.00 EUR
Supplier

Details

Description
Phlorizin is a competitive inhibitor of SGLT1 (sodium glucose co-transporter 1) and SGLT2 (sodium glucose co-transporter 2); this reduces renal glucose transport, lowering the amount of glucose in the blood. It competitively inhibits the initial rate of α-methyl-D-glucopyranoside (α-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC₅₀ values of 400 and 65 nM, respectively. In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.
Peptide sequence
N/A
CAS number
60-81-1
Molecular weight
436.41
Category
Biochemicals
Other name
1-​[2-​(β-​D-​glucopyranosyloxy)-​4,​6-​dihydroxyphenyl]-​3-​(4-​hydroxyphenyl)-​1-​propanone; NSC 2833; Florizidin
Molecular formula
C₂₁H₂₄O₁₀
Physical appearance
White to yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
No
Purification
≥98%
Reconstitute instructions
DMSO (~30 mg/ml) or EtOH (~ 5 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.