AM580 for cell activation

Catalog number
2635-1
Name
AM580 for cell activation
Size
1 mg
Price
121.00 EUR
Supplier

Details

Description
AM580 is an analog of Retinoic acid (Cat. No. 2218) that acts as aretinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC₅₀ = 0.36 nM) compared to RARβ (Kd = 131 nM; AC₅₀ = 24.6 nM) and RARγ (Kd = 450 nM; AC₅₀ = 27.9 nM). It displays greater specific binding to RARα compared to retinoic acid which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Cat. No.1677) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.
Peptide sequence
N/A
CAS number
102121-60-8
Molecular weight
351.44
Category
Biochemicals
Other name
4-​​[[(5,​​6,​​7,​​8-​​tetrahydro-​​5,​​5,​​8,​​8-​​tetramethyl-​​2-​​naphthalenyl)​carbonyl]​amino]​-​benzoic acid; RO 40-6055; CD336; NSC 608001
Molecular formula
C₂₂H₂₅NO₃
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>98%
Reconstitute instructions
DMSO (~ 15 mg/ml)
Storage condition
-20 ̊C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.