KW-2449 hydrochloride for cell activation

Catalog number
B1208-5
Name
KW-2449 hydrochloride for cell activation
Size
5 mg
Price
175.00 EUR
Supplier

Details

Description
KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. It displays potent inhibition of growth effects on leukemia cells with FLT3 mutations via inhibition of the FLT3 kinase. This leads in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis. KW 2449 induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis in FLT3 wild-type human leukemia.
Peptide sequence
N/A
CAS number
1000669-72-6
Molecular weight
368.86
Category
Biochemicals
Other name
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
Molecular formula
C₂₀H₂₀N₄O. HCl
Physical appearance
Crystalline Solid
Supplied with
N/A
Is this a salt?
Yes
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO(>30 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.