anti-TLR5(Toll-like receptor 5) Polyclonal Antibody

Catalog number
3555-100
Name
anti-TLR5(Toll-like receptor 5) Polyclonal Antibody
Size
TLR5(Toll-like receptor 5) Polyclonal Antibody
Price
371.00 EUR
Supplier

Details

Target of this antibody:
TLR5(Toll-like receptor 5)
Alternative names of antibody target:
Toll Like Receptor 5
Background information:
The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology(TH) domain,which is essential for Toll-induced signal transduction.TLR1,as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride(LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. TLR6 is highly homologous to TLR1, and like other members of TLR family, it induces NFkB Signaling upon activation. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes.
Antibody host:
Rabbit
Clonality of antibody:
Polyclonal
Isotype:
rabbit IgG
Clone:
N/A
This antibody reacts with:
Human, Mouse, Rat
Immunogene sequence:
Synthetic peptide surrounding amino acid 330 of human TLR5
Concentration of antibody:
0.5 mg/ml
Form of antibody:
Liquid
Formulation of this antibody:
100 ml protein A purified rabbit anti-TLR5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 10% glycerol and 0.02% thimerosal.
Purification method:
Affinity purified rabbit IgG
This antibody has been succesfully tested for use in following methods:
Western blot
Recommended usage:
Western blot: 1-4 µg
Storage information:
Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions:
gel pack
How to handle this antibody:
The antibody solution should be gently mixed before use.
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Group
Polyclonals and antibodies
About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
French translation
anticorps