Target of this antibody:
Alternative names of antibody target:
F-Box-Like/WD Repeat-Containing Protein; Transducin β-Like 1X-Related Protein 1
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thoμght to mediate repression, at least in part, by their ability to recruit histone deacetylases (HDAC) to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes and its presence is thoμght to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Althoμgh TBLR1 is thoμght to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
Clonality of antibody:
This antibody reacts with:
Human, mouse, rat
Synthetic peptide from human TBLR1 within the region of amino acids 200-250.
Concentration of antibody:
Form of antibody:
Formulation of this antibody:
50 µg of antibody in 100 µl PBS containing 0.2% gelatin and 0.05% sodium azide.
Protein G purified
This antibody has been succesfully tested for use in following methods:
Western blot: 1-3 µg/ml. However, the optimal conditions should be determined individually.
Shelf time: 12 months in temp.: -20 deg.C
How to handle this antibody:
The antibody solution should be gently mixed before use.
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.