Doramapimod for cell activation

Catalog number
1954-25
Name
Doramapimod for cell activation
Size
25 mg
Price
382.00 EUR
Supplier

Details

Description
Cell-permeable. A potent protein kinase inhibitor with a>330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK.
Peptide sequence
N/A
CAS number
285983-48-4
Molecular weight
527.66
Category
Biochemicals
Other name
1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796
Molecular formula
C₃₁H₃₇N₅O₃
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~50 mg/ml) or EtOH (~ 30 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
48 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.