IGF-BP1, human recombinant

Catalog number
4717-100
Name
IGF-BP1, human recombinant
Size
100 μg
Price
675.00 EUR
Supplier

Details

Synonyms
IGF-BP1, human recombinant
Alternates names
IBP-1, IGF-Binding Protein 1, AFBP, PP12, IGF-BP25, hIGFBP-1, IGFBP-1.
Taglines
A protein which binds and prolongs the half-life of the IGFs
Biomolecule/Target
NA
NCBI Gene ID #.
3484
NCBI Gene Symbol
IBP1
Gene Source
Human
Accession #
P08833
Recombinant
Yes
Source
Nso cells
Purity
≥98%
Activity (Specifications/test method)
N/A
Biological activity
The ED₅₀ as determined by its ability to inhibit IGF-I induced proliferation of NUC-1 cells is ~100 ng/ml.
Results
~100 ng/ml
Molecular Weight
28.8 kDa
Storage Temp.
-20°C
Shipping
Gel pack
Shelf Life
1 year
Concentration
N/A
Appearance
Lyophilized protein
Physical form description
Sterile filtered and lyophilized with no additives
Reconstitution Instructions
Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use.
Handling
Centrifuge the vial prior to opening.
Usage
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description
IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
Additional source
Recombinants or rec. proteins
Group
recombinants