DAPT for cell activation

Catalog number
1855-5
Name
DAPT for cell activation
Size
5 mg
Price
240.00 EUR
Supplier

Details

Description
Cell permeable. A potent inhibitor of γ-secretase (IC₅₀ = 115 nM for total β-amyloid, IC₅₀ = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.
Peptide sequence
N/A
CAS number
208255-80-5
Molecular weight
432.46
Category
Biochemicals
Other name
N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
Molecular formula
C₂₃H₂₆F₂N₂O₄
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by TLC
Reconstitute instructions
DMSO (~20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.