PYR-41 for cell activation

Catalog number
1925-5
Name
PYR-41 for cell activation
Size
5 mg
Price
148.00 EUR
Supplier

Details

Description
Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ <10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
Peptide sequence
N/A
CAS number
418805-02-4
Molecular weight
371.3
Category
Biochemicals
Other name
4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Molecular formula
C₁₇H₁₃N₃O₇
Physical appearance
Brown solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by TLC
Reconstitute instructions
DMSO (~25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.