Myeloperoxidase Inhibitor for cell activation

Catalog number
1977-100
Name
Myeloperoxidase Inhibitor for cell activation
Size
100 mg
Price
115.00 EUR
Supplier

Details

Description
A potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC₅₀ = 300 nM). Does not affect catalase or glutathione peroxidase activities. Also displays no effect on the production of superoxide by neutrophils. Shown to inhibit H₂O₂-induced apoptosis in HL-60, human leukemia cells.
Peptide sequence
N/A
CAS number
5351-17-7
Molecular weight
151.17
Category
Biochemicals
Other name
4-Aminobenzoic hydrazide; MPO Inhibitor; 4-ABH
Molecular formula
C₇H9N₃O
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
48 months
Storage instructions
Protect from light and mositure
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.