Chelerythrine chloride for cell activation

Cell-permeable. A selective protein kinase C (PKC) inhibitor (IC₅₀ =0.66 µM). Chelerythrine is at least 100-fold more selective for PKCs than for other kinases. It induces apoptotic cell death in polymorphonuclear leukocyte through activation of caspase-3. In addition, Chelerythrine treated cells underwent apoptosis, with features that suggest involvement of the mitochondrial pathway, and through a mechanism that involves inhibition of the anti-apoptotic inhibitor BclXL.

N/A

3895-92-9

383.82

Biochemicals

1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

C₂₁H₁₈NO₄Cl

Yellow to orange solid

N/A

N/A

Yes

≥98% by HPLC

DMSO (> 10 mg/ml) or H₂O (5 mg/ml)

-20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.