SIRT2 Inhibitor, B2 for cell activation

Catalog number
2085-5
Name
SIRT2 Inhibitor, B2 for cell activation
Size
5 mg
Price
240.00 EUR
Supplier

Details

Description
Cell-permeable. A Sirtuin 2 (SIRT2) inhibitor (IC50 = 35 µM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.
Peptide sequence
N/A
CAS number
115687-05-3
Molecular weight
396.83
Category
Biochemicals
Other name
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, CPNQ
Molecular formula
C₂₀H₁₇ClN₄O₃
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
Yes
Purification
≥95%
Reconstitute instructions
DMSO (>5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.