USP7/USP47 Inhibitor, P 22077 for cell activation

Catalog number
2301-25
Name
USP7/USP47 Inhibitor, P 22077 for cell activation
Size
25 mg
Price
371.00 EUR
Supplier

Details

Description
A cell-permeable inhibitor of the ubiquitin-specific protease (IC₅₀ = 8.6 µM) and the closely related deubiquitinase (DUB) USP47. P22077 displays weak or no inhibition (EC₅₀>50 µM) towards a panel of 14 isopeptidases and other proteases. Inhibits USP7-mediated p53 deubiquitination.
Peptide sequence
No
CAS number
1247819-59-5
Molecular weight
315.32
Category
Biochemicals
Other name
1-(5-(2,4-Difluorophenylthio)-4-nitrothiophen-2-yl)ethanone; DUB inhibitor
Molecular formula
C₁₂H₇F₂NO₃S₂
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~ 30 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.