EZH2 Inhibitor, EPZ005687 for cell activation

Catalog number
2364-10
Name
EZH2 Inhibitor, EPZ005687 for cell activation
Size
10 mg
Price
480.00 EUR
Supplier

Details

Description
A potent and selective inhibitor of histone lysine N-methyltransferase EZH2 (Ki = 24 nM). It displays more than 500-fold selectivity against 15 other protein methyltransferases and has 50-fold selectivity against the closely related enzyme, EZH1.
Peptide sequence
N/A
CAS number
1396772-26-1
Molecular weight
539.67
Category
Biochemicals
Other name
1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide
Molecular formula
C₃₂H₃₇N₅O₃
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
No
Purification
≥99%HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.