AGI-5198 for cell activation
Catalog number
2369-5
Name
AGI-5198 for cell activation
Size
5 mg
Price
403.00 EUR
Supplier
Details
Description
A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1). AGI-5198 inhibits IDH1 R132H and R132C mutants in vitro with IC₅₀ values of 0.07 and 0.16 µM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC₅₀ s > 100 μM). Under conditions of near complete 2-HG (2-hydroxyglutarate) inhibition, AGI-5198 can induce demethylation of histone H3K9me3 and expression
Peptide sequence
N/A
CAS number
1355326-35-0
Molecular weight
462.56
Category
Biochemicals
Other name
N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide; IDH-C35
Molecular formula
C₂₇H₃₁FN₄O₂
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~25 mg/ml) or Ethanol (~ 15 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
