Human CellExp™ GITR / TNFRSF18, Human recombinant

Catalog number

9231-50

Size

50 µg

Price

713.00 EUR

Supplier

Biovision

Order

Details

Target

GITR

Background

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Concentration

N/A

Molecular weight

This protein is fused with a 6× His tag at C-terminus and has a calculated MW of 15.4 kDa. The protein migrates as 22-25 kDa in SDS-PAGE due to glycosylation.

Synonym

AITR, GITR, TNFRSF18, CD358

Other name

AITR, GITR, TNFRSF18, CD358

NCBI gene number

8784

NCBI gene

TNFRSF19

Gene source

Human

NCBI number

Q9Y5U5-2

Recombinant

Yes

Source

HEK 293 cells

Purification

≥92%

Tested applications

SDS-PAGE, N/A

Level of endotoxin

< 1 EU/μg

Tested activity

Measured by its binding ability in a functional ELISA.

Biological activity

Immobilized Human GITR/TNFRSF18, His Tag at 2 µg/mL (100 µL/well) can bind r-Human GITR Ligand /TNFSF18 with a linear range of 0.8-25 ng/mL.

Reesults

N/A

Binding ability

Immobilized Human GITR/TNFRSF18, His Tag at 2 µg/mL (100 µL/well) can bind r-Human GITR Ligand /TNFSF18 with a linear range of 0.8-25 ng/mL.

Unit

N/A

Storage condition

-20°C

Shipping under

Gel pack

Physical appearance

Lyophilized

Physical properties

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

How to reconstitute

Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml

Aa sequence

N/A

Before use

Centrifuge the vial prior to opening.

Notes

For Research Use Only! Not to be used in humans

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Additional source

Recombinants or rec. proteins

Group

recombinants