Human CellExp™ OX40 Ligand / TNFSF4, Human recombinant

Catalog number
9244-50
Name
Human CellExp™ OX40 Ligand / TNFSF4, Human recombinant
Size
50 µg
Price
458.00 EUR
Supplier

Details

Target
TNFRSF4
Background
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
Concentration
N/A
Molecular weight
This protein is fused with a Fc tag at C-terminus and has a calculated MW of 20 kDa.
Synonym
OX40L,TNFSF4,CD252
Other name
OX40L,TNFSF4,CD253
NCBI gene number
7293
NCBI gene
TNFRSF4
Gene source
Human
NCBI number
NP_003317
Recombinant
Yes
Source
HEK 293 cells
Purification
>95%
Tested applications
SDS-PAGE, N/A
Level of endotoxin
< 1 EU/μg
Tested activity
Measured by its binding ability in a functional ELISA.
Biological activity
Immobilized HumanOX40, His Tag at 2 μg/ml (100 μl/well) can bind Human OX40 Ligand, Fc Tag with a linear range of 2-15 ng/ml.
Reesults
N/A
Binding ability
Immobilized HumanOX40, His Tag at 2 μg/ml (100 μl/well) can bind Human OX40 Ligand, Fc Tag with a linear range of 2-15 ng/ml.
Unit
N/A
Storage condition
-20°C
Shipping under
Gel pack
Physical appearance
Lyophilized
Physical properties
Lyophilized
How to reconstitute
Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
Additional source
Recombinants or rec. proteins
Group
recombinants