EZSolution™ WP1066 for cell activation

Catalog number
2546-5
Name
EZSolution™ WP1066 for cell activation
Size
5 mg
Price
164.00 EUR
Supplier

Details

Description
A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.
Peptide sequence
N/A
CAS number
857064-38-1
Molecular weight
356.22
Category
Biochemicals
Other name
(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Molecular formula
C₁₇H₁₄BrN₃O
Physical appearance
Liquid
Supplied with
A 10 mM solution in anhydrous DMSO
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥97% by HPLC
Reconstitute instructions
N/A
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
12 months
Storage instructions
Protect from moisture and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.