IWP-4 for cell activation

Catalog number
2650-5
Name
IWP-4 for cell activation
Size
5 mg
Price
371.00 EUR
Supplier

Details

Description
IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC₅₀ = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.
Peptide sequence
N/A
CAS number
686772-17-8
Molecular weight
496.62
Category
Biochemicals
Other name
N-​(6-​methyl-​2-​benzothiazolyl)-​2-​[[3,​4,​6,​7-​tetrahydro-​3-​(2-​methoxyphenyl)-​4-​oxothieno[3,​2-​d]pyrimidin-​2-​yl]thio]-​acetamide
Molecular formula
C₂₃H₂₀N₄O₃S₃
Physical appearance
Crystaline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95% by HPLC
Reconstitute instructions
DMSO (~2 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.