ITD-1 for cell activation

Catalog number
2879-10
Name
ITD-1 for cell activation
Size
10 mg
Price
197.00 EUR
Supplier

Details

Description
ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 µM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC₅₀ =  0.4–0.8 µM), revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate. ITD-1 does not induce differentiation of vascular smooth muscle cells or endothelial cells.
Peptide sequence
N/A
CAS number
1099644-42-4
Molecular weight
415.52
Category
Biochemicals
Other name
4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
Molecular formula
C₂₇H₂₉NO₃
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~8 mg/ml) or EtOH (~4 mg/ml with warming)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.