STIMA-1 for cell activation

Catalog number
9437-50
Name
STIMA-1 for cell activation
Size
50 mg
Price
545.00 EUR
Supplier

Details

Description
STIMA-1 (SH group-targeting compound that induces massive apoptosis) reactivates mutant p53. STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells. STIMA-1 is shown to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.
Peptide sequence
N/A
CAS number
91634-12-7
Molecular weight
172.19
Category
Biochemicals
Other name
2-Vinyl-4H-quinazolinol; SH group-targeting compound that induces massive apoptosis
Molecular formula
C₁₀H₈N₂O
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥97%
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.