U-104 for cell activation

Catalog number
9631-25
Name
U-104 for cell activation
Size
25 mg
Price
414.00 EUR
Supplier

Details

Description
U-104 is a ureido-sulfonamide inhibitor of transmembrane carbonic anhydrase IX (CAIX) (Ki = 45.1 nM) and XII (CAXII) (Ki = 4.5 nM). It displays weaker affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 µM, respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.
Peptide sequence
N/A
CAS number
178606-66-1
Molecular weight
309.32
Category
Biochemicals
Other name
1-(4-fluorophenyl)-3-(4-sulfamoylphenyl)urea; NSC-213841
Molecular formula
C₁₃H₁₂FN₃O₃S
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.