MCC950 sodium for cell activation
Catalog number
9686-1
Name
MCC950 sodium for cell activation
Size
1 mg
Price
175.00 EUR
Supplier
Details
Description
MCC950 sodium is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Also glutathione S-transferase omega 1 inhibitor. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.
Peptide sequence
N/A
CAS number
256373-96-3
Molecular weight
426.46
Category
Biochemicals
Other name
N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CP-456,773; CRID3
Molecular formula
C₂₀H₂₃N₂NaO₅S
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>35 mg/ml) or H2O (>30 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
