Azidothymidine for cell activation

Catalog number
B1113-50
Name
Azidothymidine for cell activation
Size
50 mg
Price
295.00 EUR
Supplier

Details

Description
Azidothymidine is a nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC₅₀ = 3 nM) with low cytotoxicity (CC₅₀ > 5 μM). Displays 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. Suppresses HIV-1 replication and enhances cell viability in HIV-1 infected T cells. Antiretroviral agent. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency.
Peptide sequence
N/A
CAS number
30516-87-1
Molecular weight
267.24
Category
Biochemicals
Other name
3'-Azido-3'-deoxythymidine; AZT; Zidovudine
Molecular formula
C₁₀H₁₃N₅O₄
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>25 mg/ml) or H2O (>10 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.