KU-0060648 for cell activation
Catalog number
B1115-25
Name
KU-0060648 for cell activation
Size
25 mg
Price
632.00 EUR
Supplier
Details
Description
KU-0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC₅₀ = 8.6 nM). Displays 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ).
Peptide sequence
N/A
CAS number
881375-00-4
Molecular weight
582.71
Category
Biochemicals
Other name
4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide
Molecular formula
C₃₃H₃₄N₄O₄S
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
Aqueous HCl (>50 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
